Multiple sclerosis: When to suspect - Keys to diagnosis

David C Hess, Mary D. Hughes

Research output: Contribution to journalReview articlepeer-review


Multiple sclerosis (MS) is characterized by a typical clinical history of neurologic symptoms, separated in time and space, supported by laboratory tests. Key symptoms that signal MS-particularly in young adults-include unilateral vision loss, diplopia that lasts for days or weeks, and hemiparesis that has an insidious or slow onset. A Lhermitte sign can often be elicited, although this finding is not specific for MS. An MRI scan typically shows high-signal lesions on T2-weighted images in the periventricular white matter and often in the cerebellum and brainstem. The presence of oligoclonal bands in the cerebrospinal fluid is a useful but not essential finding to support the diagnosis of MS.

Original languageEnglish (US)
Pages (from-to)844-852
Number of pages9
Issue number8
StatePublished - Jul 1 2005


  • Multiple sclerosis
  • Optic neuritis

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Multiple sclerosis: When to suspect - Keys to diagnosis'. Together they form a unique fingerprint.

Cite this