Abstract
Around 20% of patients with myasthenia gravis are acetylcholine receptor antibody negative; muscle-specific tyrosine kinase antibodies (MuSK) were identified as the cause of myasthenia gravis in 30% to 40% of these cases. Anti MuSK myasthenia gravis is associated with specific clinical phenotypes. One is a bulbar form with fewer ocular symptoms. Others show an isolated head drop or symptoms indistinguishable from acetylcholine receptor-positive myasthenia gravis. These patients usually respond well to immunosuppressive therapy, but not as well to cholinesterase inhibitors. Other antibodies associated with myasthenia gravis, including low-density lipoprotein receptor-related protein 4, are discussed.
Original language | English (US) |
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Pages (from-to) | 293-310 |
Number of pages | 18 |
Journal | Neurologic Clinics |
Volume | 36 |
Issue number | 2 |
DOIs | |
State | Published - May 2018 |
Keywords
- Agrin
- Cortactin
- LRP4
- MuSK
- Myasthenia gravis
- Rapsyn
ASJC Scopus subject areas
- Clinical Neurology