MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction

Arnab Barik; Wen Cheng Xiong; Lin Mei

doi:10.1007/978-1-61779-824-5_11

MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction

Arnab Barik, Wen Cheng Xiong, Lin Mei

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

Original language	English (US)
Title of host publication	Neuromethods
Publisher	Humana Press Inc.
Pages	203-217
Number of pages	15
DOIs	https://doi.org/10.1007/978-1-61779-824-5_11
State	Published - Jan 1 2012
Externally published	Yes

Publication series

Name	Neuromethods
Volume	68
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Keywords

AChR Pre-patterning
Agrin hypothesis
Juxtamembrane domain
Lrp4
MASC
Neuromuscular junction

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-61779-824-5_11

Cite this

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title = "MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction",

abstract = "Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.",

keywords = "AChR Pre-patterning, Agrin hypothesis, Juxtamembrane domain, Lrp4, MASC, Neuromuscular junction",

author = "Arnab Barik and Xiong, {Wen Cheng} and Lin Mei",

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AU - Barik, Arnab

AU - Xiong, Wen Cheng

AU - Mei, Lin

PY - 2012/1/1

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N2 - Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

AB - Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

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KW - Juxtamembrane domain

KW - Lrp4

KW - MASC

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BT - Neuromethods

PB - Humana Press Inc.

ER -

MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

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