Abstract
Follicle-stimulating hormone (FSH), a dimeric glycoprotein synthesized in the anterior pituitary gland, is important for the production of sex steroids and gametes. FSH-beta (FSHβ) and FSH receptor (FSHR) knockout mice display impaired ovarian follicular development and infertility in females and small testes, oligospermia, and fertility in males. Humans with FSHβ gene mutations tend to have a more severe phenotype than those with FSHR gene mutations, although infertility and varying degrees of impaired sex steroid production occur in both types of mutations. Data from human and mouse mutations in the FSHβ and FSHR genes suggest that FSH is necessary for normal pubertal development and fertility in males and females.
Original language | English (US) |
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Pages (from-to) | 5-10 |
Number of pages | 6 |
Journal | Seminars in Reproductive Medicine |
Volume | 18 |
Issue number | 1 |
DOIs | |
State | Published - 2000 |
Keywords
- FSH receptor
- FSHR gene
- FSHβ gene
- Follicle-stimulating hormone
- Isolated FSH deficiency
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Reproductive Medicine
- Endocrinology
- Obstetrics and Gynecology
- Physiology (medical)