MYC as a regulator of ribosome biogenesis and protein synthesis

Jan Van Riggelen; Alper Yetil; Dean W. Felsher

doi:10.1038/nrc2819

MYC as a regulator of ribosome biogenesis and protein synthesis

Jan Van Riggelen, Alper Yetil, Dean W. Felsher

Research output: Contribution to journal › Comment/debate › peer-review

668 Scopus citations

Abstract

MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Nature Reviews Cancer
Volume	10
Issue number	4
DOIs	https://doi.org/10.1038/nrc2819
State	Published - Apr 2010
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrc2819

Cite this

@article{6e5a11807588426eb671cfee7d8e64a8,

title = "MYC as a regulator of ribosome biogenesis and protein synthesis",

abstract = "MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.",

author = "{Van Riggelen}, Jan and Alper Yetil and Felsher, {Dean W.}",

note = "Funding Information: The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01). Funding Information: We thank the Felsher laboratory for critical reading of the manuscript. Our work is supported by the National Institutes of Health, the Leukemia and Lymphoma Society and the Burroughs Wellcome Fund.",

year = "2010",

month = apr,

doi = "10.1038/nrc2819",

language = "English (US)",

volume = "10",

pages = "301--309",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - MYC as a regulator of ribosome biogenesis and protein synthesis

AU - Van Riggelen, Jan

AU - Yetil, Alper

AU - Felsher, Dean W.

N1 - Funding Information: The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01). Funding Information: We thank the Felsher laboratory for critical reading of the manuscript. Our work is supported by the National Institutes of Health, the Leukemia and Lymphoma Society and the Burroughs Wellcome Fund.

PY - 2010/4

Y1 - 2010/4

N2 - MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

AB - MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=77949920493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949920493&partnerID=8YFLogxK

U2 - 10.1038/nrc2819

DO - 10.1038/nrc2819

M3 - Comment/debate

C2 - 20332779

AN - SCOPUS:77949920493

SN - 1474-175X

VL - 10

SP - 301

EP - 309

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 4

ER -

MYC as a regulator of ribosome biogenesis and protein synthesis

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this