Myeloid cells in atherosclerosis: A delicate balance of anti-inflammatory and proinflammatory mechanisms

Ekaterina K. Koltsova, Catherine C. Hedrick, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


PURPOSE OF REVIEW: Atherosclerosis is chronic disease, whose progression is orchestrated by the balance between proinflammatory and anti-inflammatory mechanisms. Various myeloid cells, including monocytes, macrophages, dendritic cells and neutrophils can be found in normal and atherosclerotic aortas, in which they regulate inflammation and progression of atherosclerosis. The lineage relationship between blood monocyte subsets and the various phenotypes and functions of myeloid cells in diseased aortas is under active investigation. RECENT FINDINGS: Various subsets of myeloid cells play diverse roles in atherosclerosis. This review discusses new findings in phenotypic and functional characterization of different subsets of macrophages, in part determined by the transcription factors IRF5 and Trib1, and dendritic cells, characterized by the transcription factor Zbtb46, in atherosclerosis. SUMMARY: Improved understanding proinflammatory and anti-inflammatory mechanisms of macrophages and dendritic cell functions is needed for better preventive and therapeutic measures in atherosclerosis.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalCurrent Opinion in Lipidology
Issue number5
StatePublished - Oct 2013
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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