Nanostructured microcantilevers with functionalized cyclodextrin receptor phases: Self-assembled monolayers and vapor-deposited films

Christopher A. Tipple, Nickolay V. Lavrik, Mustafa Culha, Jeremy Headrick, Panos Datskos, Michael J. Sepaniak

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

It is shown that the performance of microcantilver-based chemical sensors in a liquid environment is affected by altering cantilever surface morphology and receptor phase type and thickness. Self-assembled monolayers of thiolated β-cyclodextrin (HM-β-CD) and thin films of vapor-deposited heptakis (2,3-O-diacetyl-6-O-tertbutyl-dimethylsilyl)-β-cyclodextrin (HDATB-β-CD) were studied on smooth and nanostructured (dealloyed) gold-coated microcantilever surfaces. The dealloyed surface contains nanometer-sized features that enhance the transduction of molecular recognition events into cantilever response, as well as increase film stability for thicker films. Improvements in the limits of detection of the compound 2,3-dihydroxynaphthalene as great as 2 orders of magnitude have been achieved by manipulating surface morphology and film thickness. The observed response factors for the analytes studied varied from 0.02-604 nm/ppm, as determined by cantilever deflection. In general, calibration plots for the analytes were linear up to several hundred nanometers in cantilever deflections.

Original languageEnglish (US)
Pages (from-to)3118-3126
Number of pages9
JournalAnalytical Chemistry
Volume74
Issue number13
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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