TY - JOUR
T1 - Neonatal Microbiome and Its Relationship to Necrotizing Enterocolitis
T2 - A Review of the Science
AU - Mattern, Jordan
AU - Marin, Terri
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Necrotizing enterocolitis (NEC) occurs in many premature infants hospitalized in the neonatal intensive care unit. About 3% to 15% of very low-weight premature infants develop NEC, with an estimated 30% mortality rate for the cases requiring surgery. Currently, there is no known pathogenesis for NEC in the patient's populations. However, one of the most widely accepted hypotheses is having an abnormal fetal gut microbiome. The purpose of this review is to discuss some current methods of dysbiosis in the neonatal microbiome, such as maternal health, breastfeeding, and delivery method, and then to connect these to the occurrence of NEC in the infant and finally discuss some possibilities for limiting the occurrence of NEC in the future.
AB - Necrotizing enterocolitis (NEC) occurs in many premature infants hospitalized in the neonatal intensive care unit. About 3% to 15% of very low-weight premature infants develop NEC, with an estimated 30% mortality rate for the cases requiring surgery. Currently, there is no known pathogenesis for NEC in the patient's populations. However, one of the most widely accepted hypotheses is having an abnormal fetal gut microbiome. The purpose of this review is to discuss some current methods of dysbiosis in the neonatal microbiome, such as maternal health, breastfeeding, and delivery method, and then to connect these to the occurrence of NEC in the infant and finally discuss some possibilities for limiting the occurrence of NEC in the future.
KW - diseases of prematurity
KW - dysbiosis
KW - necrotizing enterocolitis
KW - neonatal microbiome
UR - http://www.scopus.com/inward/record.url?scp=85088475265&partnerID=8YFLogxK
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U2 - 10.1097/JPN.0000000000000507
DO - 10.1097/JPN.0000000000000507
M3 - Article
C2 - 32697548
AN - SCOPUS:85088475265
SN - 0893-2190
VL - 34
SP - 276
EP - 282
JO - Journal of Perinatal and Neonatal Nursing
JF - Journal of Perinatal and Neonatal Nursing
IS - 3
ER -