Nephropathy in the Wiskott-Aldrich syndrome

L. E. Spitler, B. B. Wray, S. Mogerman, J. J. Miller IIIrd, R. J. O'Reilly, M. Lagios

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Nephropathy was detected in 5 of 32 patients with the Wiskott-Aldrich syndrome who were participating in a study of transfer factor (TF) therapy. In two patients, nephropathy was present before TF and did not appear changed by TF therapy. One of these patients subsequently developed progressive renal failure requiring dialysis beginning 5 1/2 years after TF therapy. In 2 patients, decreased renal function appeared very soon after the administration of TF. One patient showed gradually decreasing renal function beginning after 2 years of TF therapy. An additional patient was identified who died with renal failure without having received TF. The results suggest that renal failure occurs in the Wiskott-Aldrich syndrome more frequently than generally recognized and that administration of TF may precipitate or accelerate the renal disease in patients with this syndrome.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
Issue number3
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Nephropathy in the Wiskott-Aldrich syndrome'. Together they form a unique fingerprint.

Cite this