Neural crest cells contribute to normal aorticopulmonary septation

Margaret L. Kirby; Thomas F. Gale; Donald E. Stewart

doi:10.1126/science.6844926

Neural crest cells contribute to normal aorticopulmonary septation

Margaret L. Kirby, Thomas F. Gale, Donald E. Stewart

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

Original language	English (US)
Pages (from-to)	1059-1061
Number of pages	3
Journal	Science
Volume	220
Issue number	4601
DOIs	https://doi.org/10.1126/science.6844926
State	Published - 1983

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title = "Neural crest cells contribute to normal aorticopulmonary septation",

abstract = "By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.",

author = "Kirby, {Margaret L.} and Gale, {Thomas F.} and Stewart, {Donald E.}",

year = "1983",

doi = "10.1126/science.6844926",

language = "English (US)",

volume = "220",

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journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - Neural crest cells contribute to normal aorticopulmonary septation

AU - Kirby, Margaret L.

AU - Gale, Thomas F.

AU - Stewart, Donald E.

PY - 1983

Y1 - 1983

N2 - By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

AB - By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

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U2 - 10.1126/science.6844926

DO - 10.1126/science.6844926

M3 - Article

C2 - 6844926

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SN - 0036-8075

VL - 220

SP - 1059

EP - 1061

JO - Science

JF - Science

IS - 4601

ER -

Neural crest cells contribute to normal aorticopulmonary septation

Abstract

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