Neural crest cells contribute to normal aorticopulmonary septation

Margaret L. Kirby, Thomas F. Gale, Donald E. Stewart

Research output: Contribution to journalArticlepeer-review

301 Scopus citations


By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

Original languageEnglish (US)
Pages (from-to)1059-1061
Number of pages3
Issue number4601
StatePublished - 1983

ASJC Scopus subject areas

  • General


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