Neurocognitive and behavioral profiles of children with Landau-Kleffner syndrome

Cynthia A. Riccio, Stephanie M. Vidrine, Morris J. Cohen, Delmaris Acosta-Cotte, Yong Park

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This is a retrospective study of 14 cases of children with Landau-Kleffner syndrome (LKS), the most prominent feature of which is acquired aphasia. These children were followed at a tertiary care pediatric epilepsy center. From the research data base, all LKS cases with neuropsychological evaluation were extracted. Children ranged in age from 6 to 13 years (M = 9.12; SD = 2.19) at the time of assessment (1 to 10 years post-onset). The majority of the children were white males, and all but one continued to experience seizure activity. Global intellectual functioning ranged from 59 to 101 (M = 82.07; SD = 12.14). Across the 14 cases reviewed, the neuropsychological profiles are considered in the context of neurological and syndrome-related factors. For these cases, 86% demonstrated continued expressive, and 50% had receptive language problems with 57% exhibiting poor auditory processing. Furthermore, 50 to 57% had deficits in auditory working memory and verbal memory. Academically, the majority had poor reading fluency and comprehension; 50% exhibited difficulty with mathematics. Finally, 57% evidenced attentional or other behavioral problems. Better understanding of LKS can assist in targeted assessment and intervention planning.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
JournalApplied Neuropsychology: Child
Issue number4
StatePublished - Oct 2 2017


  • Aphasia
  • Landau-Kleffner syndrome
  • epilepsy
  • inattention

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology


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