TY - JOUR
T1 - Neutrophil extracellular traps in ischemic AKI
T2 - new way to kill
AU - Liu, Jing
AU - Dong, Zheng
N1 - Funding Information:
We thank Dr. Hans-Joachim Anders (Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany) for reading this commentary before submission for publication. The authors’ work was supported by grants from the National Natural Science Foundation of China (81370791, 81430017), the China Scholarship Council, the National Institutes of Health (2R01DK058831, 1R01 DK087843) of the United States, and the Department of Veterans Administration (5I01BX000319) of the United States.
Publisher Copyright:
© 2017 International Society of Nephrology
PY - 2018/2
Y1 - 2018/2
N2 - Neutrophil extracellular traps, originally discovered as a mechanism to combat microbial infection, have recently been implicated in tissue damage including acute kidney injury. Raup-Konsavage et al. now present further insights to demonstrate a critical role of neutrophil peptidyl arginine deiminase-4 in the formation of neutrophil extracellular trap, inflammation, and tissue damage in ischemic acute kidney infection. Targeting peptidyl arginine deiminase-4 and/or neutrophil extracellular trap may offer a new therapeutic strategy for acute kidney infection.
AB - Neutrophil extracellular traps, originally discovered as a mechanism to combat microbial infection, have recently been implicated in tissue damage including acute kidney injury. Raup-Konsavage et al. now present further insights to demonstrate a critical role of neutrophil peptidyl arginine deiminase-4 in the formation of neutrophil extracellular trap, inflammation, and tissue damage in ischemic acute kidney infection. Targeting peptidyl arginine deiminase-4 and/or neutrophil extracellular trap may offer a new therapeutic strategy for acute kidney infection.
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U2 - 10.1016/j.kint.2017.09.031
DO - 10.1016/j.kint.2017.09.031
M3 - Comment/debate
C2 - 29389395
AN - SCOPUS:85041582731
SN - 0085-2538
VL - 93
SP - 303
EP - 305
JO - Kidney International
JF - Kidney International
IS - 2
ER -