@article{6f616bc0388f4a189f5944497f162a35,
title = "Neutrophils: New insights and open questions",
abstract = "Neutrophils are the first line of defense against bacteria and fungi and help combat parasites and viruses. They are necessary for mammalian life, and their failure to recover after myeloablation is fatal. Neutrophils are short-lived, effective killing machines. Their life span is significantly extended under infectious and inflammatory conditions. Neutrophils take their cues directly from the infectious organism, from tissue macrophages and other elements of the immune system. Here, we review how neutrophils traffic to sites of infection or tissue injury, how they trap and kill bacteria, how they shape innate and adaptive immune responses, and the pathophysiology of monogenic neutrophil disorders.",
author = "Klaus Ley and Hoffman, {Hal M.} and Paul Kubes and Cassatella, {Marco A.} and Arturo Zychlinsky and Hedrick, {Catherine C.} and Catz, {Sergio D.}",
note = "Funding Information: We apologize to all investigators whose excellent neutrophil work is not cited in this Review because of the limited number of references allowed. In some cases, we were only able to cite recent reviews and not the original work This work was supported by Public Health Service NIH grant P01 HL078784 to K.L.; Public Health Service NIH grants R01 DK113592 and R01 HL140898 to H.M.H.; Public Health Service NIH grants P01 HL136275 and R01 CA202987 to C.C.H.; Associazione Italiana per la Ricerca sul Cancro (AIRC, IG-20339) and Ministero dell{\textquoteright}Istruzione, dell{\textquoteright}Universit{\`a} e della Ricerca (PRIN 2015YYKPNN) to M.A.C.; CIHR Foundation Grant to P.K.; and U.S. Public Health Service NIH grants R01 HL088256, R01 AR070837, and R01 DK110162 to S.D.C. Publisher Copyright: Copyright {\textcopyright} 2018 The Authors, some rights reserved.",
year = "2018",
doi = "10.1126/sciimmunol.aat4579",
language = "English (US)",
volume = "3",
journal = "Science immunology",
issn = "2470-9468",
publisher = "American Association for the Advancement of Science",
number = "30",
}