Neutrophils: New insights and open questions

Klaus Ley, Hal M. Hoffman, Paul Kubes, Marco A. Cassatella, Arturo Zychlinsky, Catherine C. Hedrick, Sergio D. Catz

Research output: Contribution to journalReview articlepeer-review

258 Scopus citations


Neutrophils are the first line of defense against bacteria and fungi and help combat parasites and viruses. They are necessary for mammalian life, and their failure to recover after myeloablation is fatal. Neutrophils are short-lived, effective killing machines. Their life span is significantly extended under infectious and inflammatory conditions. Neutrophils take their cues directly from the infectious organism, from tissue macrophages and other elements of the immune system. Here, we review how neutrophils traffic to sites of infection or tissue injury, how they trap and kill bacteria, how they shape innate and adaptive immune responses, and the pathophysiology of monogenic neutrophil disorders.

Original languageEnglish (US)
Article numbereaat4579
JournalScience immunology
Issue number30
StatePublished - 2018
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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