New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Mustafa Çeşme; Harun Muslu; Mehmet Tumer; Güngör Eren; Mine Altunbek; Mustafa Culha; Aysegul Golcu

doi:10.1080/24701556.2021.2015385

New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Mustafa Çeşme, Harun Muslu, Mehmet Tumer, Güngör Eren, Mine Altunbek, Mustafa Culha, Aysegul Golcu

Research output: Contribution to journal › Article › peer-review

Abstract

The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)₂] 3H₂O; NGDCM1) and Cu(II) ([Cu(DAC)ClH₂O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (K _b) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

Original language	English (US)
Journal	Inorganic and Nano-Metal Chemistry
DOIs	https://doi.org/10.1080/24701556.2021.2015385
State	Accepted/In press - 2021
Externally published	Yes

Keywords

antineoplastic
dacarbazine
DNA binding
Metal-based drugs

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/24701556.2021.2015385

Cite this

@article{e33e3476dd514abf9b43d710198e0b69,

title = "New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties",

abstract = "The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (K b) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound{\textquoteright}s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.",

keywords = "antineoplastic, dacarbazine, DNA binding, Metal-based drugs",

author = "Mustafa {\c C}e{\c s}me and Harun Muslu and Mehmet Tumer and G{\"u}ng{\"o}r Eren and Mine Altunbek and Mustafa Culha and Aysegul Golcu",

note = "Funding Information: The authors wish to thank TUBITAK (Project No: 112T721, COST/CM1105) for the financial supports. Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2021",

doi = "10.1080/24701556.2021.2015385",

language = "English (US)",

journal = "Inorganic and Nano-Metal Chemistry",

issn = "2470-1556",

publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - New metal-based drugs

T2 - spectral, electrochemical, DNA-binding and anticancer activity properties

AU - Çeşme, Mustafa

AU - Muslu, Harun

AU - Tumer, Mehmet

AU - Eren, Güngör

AU - Altunbek, Mine

AU - Culha, Mustafa

AU - Golcu, Aysegul

PY - 2021

Y1 - 2021

N2 - The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (K b) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

AB - The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (K b) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

KW - antineoplastic

KW - dacarbazine

KW - DNA binding

KW - Metal-based drugs

UR - http://www.scopus.com/inward/record.url?scp=85121571356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85121571356&partnerID=8YFLogxK

U2 - 10.1080/24701556.2021.2015385

DO - 10.1080/24701556.2021.2015385

M3 - Article

AN - SCOPUS:85121571356

SN - 2470-1556

JO - Inorganic and Nano-Metal Chemistry

JF - Inorganic and Nano-Metal Chemistry

ER -

New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this