New targets and approaches to autoimmune-induced salivary hypofunction

Douglas Dickinson, Kalu Ogbureke, Scott De Rossi, Stephen Hsu

Research output: Chapter in Book/Report/Conference proceedingChapter


The pathogenesis of autoimmune diseases is multifaceted, and the complexity of symptoms, diagnosis and treatment options associated with these diseases reflects this. Sjogren's syndrome (SS) is an autoimmune disorder affecting up to 4 million Americans, and results from autoimmune reactions in secretory glands (primary SS) and other tissues (secondary SS). Current treatment options for SS are aimed largely at amelioration of symptoms, but without functional restoration in the secretory glands. Prescribed medications for salivary hypo-function or xerostomia are often associated with severe side effects, typically due to the effects of systemically administered muscarinic cholinergic receptor agonistis. This book presents research on novel agents for treatment of autoimmune disorders.
Original languageEnglish (US)
Title of host publicationAutoimmune Disorders: Symptoms, Diagnosis and Treatment
Subtitle of host publicationSymptoms, Diagnosis and Treatment
PublisherNova Science Publishers, Inc.
Number of pages24
ISBN (Print)9781617615528
StatePublished - Jan 1 2011

Publication series

NameImmunology and Immune System Disorders
PublisherNova Science Publishers

ASJC Scopus subject areas

  • Medicine(all)


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