Abstract
A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.
Original language | English (US) |
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Pages (from-to) | 3225-9 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 23 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2013 |
Keywords
- Amines
- Anti-Infective Agents
- Aspergillus flavus
- Aspergillus niger
- Candida albicans
- Fluorine
- Gram-Negative Bacteria
- Gram-Positive Bacteria
- Microbial Sensitivity Tests
- Quinolones
- Journal Article
- Research Support, Non-U.S. Gov't