No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Glenn Y. Deng; Noel K. Maclaren; Hong So Huang; Li Ping Zhang; Jin Xiong She

doi:10.1016/0198-8859(95)00166-2

No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Glenn Y. Deng, Noel K. Maclaren, Hong So Huang, Li Ping Zhang, Jin Xiong She

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Abstract

Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.

Original language	English (US)
Pages (from-to)	137-142
Number of pages	6
Journal	Human Immunology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(95)00166-2
State	Published - Feb 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0198-8859(95)00166-2

Cite this

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title = "No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus",

abstract = "Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.",

author = "Deng, {Glenn Y.} and Maclaren, {Noel K.} and Huang, {Hong So} and Zhang, {Li Ping} and She, {Jin Xiong}",

note = "Funding Information: This work was supported by Juvenile Diabetes Foundation Grant JDF193182 and National Institutes of Health Grant HL47 138.",

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T1 - No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

AU - Deng, Glenn Y.

AU - Maclaren, Noel K.

AU - Huang, Hong So

AU - Zhang, Li Ping

AU - She, Jin Xiong

N1 - Funding Information: This work was supported by Juvenile Diabetes Foundation Grant JDF193182 and National Institutes of Health Grant HL47 138.

PY - 1996/2

Y1 - 1996/2

N2 - Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.

AB - Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.

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No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Abstract

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UN SDGs

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