TY - JOUR
T1 - Non-alcoholic steatohepatitis
T2 - an overview including treatments with herbals as alternative therapeutics
AU - Thounaojam, Menaka Chanu
AU - Navalsinh Jadeja, Ravirajsinh
AU - Vijaysinh Devkar, Ranjisinh
AU - Vadathala Ramachandran, Ayalur
N1 - Funding Information:
Authors Menaka Chanu Thounaojam and Ravirajsinh Navalsinh Jadeja are thankful to the University Grants Commission and Council of scientific and Industrial Research, New Delhi India for providing financial assistance in the form of RFSMS and CSIR-SRF fellowships respectively.
Publisher Copyright:
© 2012 University of South Bohemia, FHSS, Ceske Budejovice, Czech Republic
PY - 2012
Y1 - 2012
N2 - Non-alcoholic steatohepatitis (NASH), an under- recognized hepatic ailment with increasing prevalence, is fast emerging as the dark horse of hepatic related morbidity and mortality. Though introduced as a hepatic condition as early as 1980, detailed exploration of its causes, underlying mechanisms and therapeutics has largely remained an ignored or neglected field. Only recently, the focus of attention has gravitated towards an understanding of NASH as a pathological manifestation of significance and a search for possible therapeutic interventions. Treatment schedules as of now involve life style management and usage of anti-diabetic or anti-obesity drugs and antioxidants. In the present review, we have focused on the available treatment schedules including herbal agents, plant extracts, polyherbal formulations and isolated phytocompounds. We present here a review of the available literature on pre-clinical and clinical evaluations of herbals including our recent findings on two plant extracts which can be used in mitigating NASH. This review attempts to provide a comprehensive account of NASH and the future of therapeutics and remediation by herbal principles, an aspect of the urgent need to target this important medical condition that contributes to many cases of silent morbidity and mortality.
AB - Non-alcoholic steatohepatitis (NASH), an under- recognized hepatic ailment with increasing prevalence, is fast emerging as the dark horse of hepatic related morbidity and mortality. Though introduced as a hepatic condition as early as 1980, detailed exploration of its causes, underlying mechanisms and therapeutics has largely remained an ignored or neglected field. Only recently, the focus of attention has gravitated towards an understanding of NASH as a pathological manifestation of significance and a search for possible therapeutic interventions. Treatment schedules as of now involve life style management and usage of anti-diabetic or anti-obesity drugs and antioxidants. In the present review, we have focused on the available treatment schedules including herbal agents, plant extracts, polyherbal formulations and isolated phytocompounds. We present here a review of the available literature on pre-clinical and clinical evaluations of herbals including our recent findings on two plant extracts which can be used in mitigating NASH. This review attempts to provide a comprehensive account of NASH and the future of therapeutics and remediation by herbal principles, an aspect of the urgent need to target this important medical condition that contributes to many cases of silent morbidity and mortality.
KW - herbal medicine
KW - non-alcoholic steatohepatitis
KW - phytocompounds
KW - polyherbal formulation
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U2 - 10.2478/v10136-012-0008-9
DO - 10.2478/v10136-012-0008-9
M3 - Review article
AN - SCOPUS:84870388034
SN - 1214-021X
VL - 10
SP - 119
EP - 136
JO - Journal of Applied Biomedicine
JF - Journal of Applied Biomedicine
IS - 3
ER -