Nonclassical Patrolling Monocyte Function in the Vasculature

Graham Thomas, Robert Tacke, Catherine C. Hedrick, Richard N. Hanna

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1highLy6C- in mouse and CX3CR1highCD14dimCD16+ in humans) are distinct from the classical monocyte subsets (CCR2highLy6C+ in mouse and CCR2highCD14+CD16- in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.

Original languageEnglish (US)
Pages (from-to)1306-1316
Number of pages11
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number6
StatePublished - Jun 27 2015
Externally publishedYes


  • atherosclerosis
  • inflammation
  • macrophages
  • monocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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