Nonclassical Patrolling Monocyte Function in the Vasculature

Graham Thomas; Robert Tacke; Catherine C. Hedrick; Richard N. Hanna

doi:10.1161/ATVBAHA.114.304650

Nonclassical Patrolling Monocyte Function in the Vasculature

Graham Thomas, Robert Tacke, Catherine C. Hedrick, Richard N. Hanna

Research output: Contribution to journal › Article › peer-review

231 Scopus citations

Abstract

Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1^highLy6C^- in mouse and CX3CR1^highCD14^dimCD16⁺ in humans) are distinct from the classical monocyte subsets (CCR2^highLy6C⁺ in mouse and CCR2^highCD14⁺CD16^- in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.

Original language	English (US)
Pages (from-to)	1306-1316
Number of pages	11
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1161/ATVBAHA.114.304650
State	Published - Jun 27 2015
Externally published	Yes

Keywords

atherosclerosis
inflammation
macrophages
monocytes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/ATVBAHA.114.304650

Cite this

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title = "Nonclassical Patrolling Monocyte Function in the Vasculature",

abstract = "Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1highLy6C- in mouse and CX3CR1highCD14dimCD16+ in humans) are distinct from the classical monocyte subsets (CCR2highLy6C+ in mouse and CCR2highCD14+CD16- in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.",

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AU - Tacke, Robert

AU - Hedrick, Catherine C.

AU - Hanna, Richard N.

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AB - Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1highLy6C- in mouse and CX3CR1highCD14dimCD16+ in humans) are distinct from the classical monocyte subsets (CCR2highLy6C+ in mouse and CCR2highCD14+CD16- in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.

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Nonclassical Patrolling Monocyte Function in the Vasculature

Abstract

Keywords

ASJC Scopus subject areas

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