TY - JOUR
T1 - Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity
AU - Kong, Feng Ming (Spring)
AU - Wang, Shulian
N1 - Funding Information:
This study was supported in part by R01CA142840.
Funding Information:
Dr. Kong has research grants from NIHR01, R21, P01 and Varian Medical System. Dr. Wang is supported by an educational grant from Varian Medical system.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.
AB - The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.
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U2 - 10.1016/j.semradonc.2014.12.003
DO - 10.1016/j.semradonc.2014.12.003
M3 - Review article
C2 - 25771414
AN - SCOPUS:84961289904
SN - 1053-4296
VL - 25
SP - 100
EP - 109
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 2
ER -
