Nonimmune hydrops fetalis: Clinical experience and factors related to a poor outcome

Ramón A. Castillo, Lawrence D Devoe, Hamid A. Hadi, Sara Martin, Dorothy Geist

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Twenty-one cases of nonimmune hydrops fetalis diagnosed at the Medical College of Georgia during a 2year period are presented. All fetuses satisfied strict diagnostic criteria and were evaluated according to a standard protocol. The corrected mortality rate was 95% with pulmonary hypoplasia being the most common cause of perinatal death. The mean gestational age at diagnosis was 24.8 weeks; in 57% of the cases the cause of nonimmune hydrops fetalis was identified. Fifteen fetuses had serial ultrasound assessment and in 19 cases postnatal evaluation was performed. Two factors that consistently conveyed a poor perinatal outcome were ultrasonographic evidence of malformation and/or the presence of persistent pleural effusions. A method for the quantification of fetal pleural effusions is presented and its clinical relevance is discussed.

Original languageEnglish (US)
Pages (from-to)812-816
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Jan 1 1986


  • Hydrops
  • nonimmune
  • pleural effusions

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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