TY - JOUR
T1 - Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents
AU - Stansfield, Brian K.
AU - Fain, Mary Ellen
AU - Bhatia, Jatinder
AU - Gutin, Bernard
AU - Nguyen, Joshua T.
AU - Pollock, Norman K.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.
AB - Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.
KW - fetal origins
KW - insulin resistance
KW - metabolic syndrome
KW - obesity
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U2 - 10.1016/j.jpeds.2016.04.012
DO - 10.1016/j.jpeds.2016.04.012
M3 - Article
C2 - 27174144
AN - SCOPUS:84965095687
SN - 0022-3476
VL - 174
SP - 185
EP - 192
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -