Noradrenergic dysfunction in Alzheimer's disease

Mary Gannon, Pulin Che, Yunjia Chen, Kai Jiao, Erik D. Roberson, Qin Wang

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout the brain via widespread efferent projections, and plays a pivotal role in modulating cognitive activities in the cortex. Profound noradrenergic degeneration in Alzheimer's disease (AD) patients has been observed for decades, with recent research suggesting that the locus coeruleus (where noradrenergic neurons are mainly located) is a predominant site where AD-related pathology begins. Mounting evidence indicates that the loss of noradrenergic innervation greatly exacerbates AD pathogenesis and progression, although the precise roles of noradrenergic components in AD pathogenesis remain unclear. The aim of this review is to summarize current findings on noradrenergic dysfunction in AD, as well as to point out deficiencies in our knowledge where more research is needed.

Original languageEnglish (US)
Article number220
JournalFrontiers in Neuroscience
Issue numberJUN
StatePublished - 2015
Externally publishedYes


  • Adrenergic receptors
  • Degeneration
  • Dysfunction
  • Noradrenergic system
  • Norepinephrine

ASJC Scopus subject areas

  • Neuroscience(all)


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