Novel Biomedical Applications of Crosslinked Collagen

Lisha Gu, Tiantian Shan, Yu xuan Ma, Franklin R. Tay, Lina Niu

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations


Collagen is one of the most useful biopolymers because of its low immunogenicity and biocompatibility. The biomedical potential of natural collagen is limited by its poor mechanical strength, thermal stability, and enzyme resistance, but exogenous chemical, physical, or biological crosslinks have been used to modify the molecular structure of collagen to minimize degradation and enhance mechanical stability. Although crosslinked collagen-based materials have been widely used in biomedicine, there is no standard crosslinking protocol that can achieve a perfect balance between stability and functional remodeling of collagen. Understanding the role of crosslinking agents in the modification of collagen performance and their potential biomedical applications are crucial for developing novel collagen-based biopolymers for therapeutic gain.

Original languageEnglish (US)
Pages (from-to)464-491
Number of pages28
JournalTrends in Biotechnology
Issue number5
StatePublished - May 2019


  • collagen
  • crosslink
  • stability
  • tissue engineering
  • tissue repair

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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