TY - JOUR
T1 - Novel strategy for septic acute kidney injury rescue
T2 - maintenance of the tubular integrity
AU - Wei, Qingqing
N1 - Publisher Copyright:
© 2020 International Society of Nephrology
PY - 2020/5
Y1 - 2020/5
N2 - Fluid resuscitation for oliguria rescue in septic acute kidney injury (AKI) has limited success. By examination of the proximal tubular integrity, Nakano et al. identified paracellular renal filtrate leakage in proximal tubules after lipopolysaccharide induced tight junction disruption to contribute to oliguria. Suppression of lipopolysaccharide injury to proximal tubules by Toll-like receptor 4 knockout significantly ameliorated the oliguria and renal function loss in septic AKI. This commentary discusses the new therapeutic strategy for septic AKI rescue by proximal tubular integrity protection and the potential impact of tight junction injury in all AKI conditions.
AB - Fluid resuscitation for oliguria rescue in septic acute kidney injury (AKI) has limited success. By examination of the proximal tubular integrity, Nakano et al. identified paracellular renal filtrate leakage in proximal tubules after lipopolysaccharide induced tight junction disruption to contribute to oliguria. Suppression of lipopolysaccharide injury to proximal tubules by Toll-like receptor 4 knockout significantly ameliorated the oliguria and renal function loss in septic AKI. This commentary discusses the new therapeutic strategy for septic AKI rescue by proximal tubular integrity protection and the potential impact of tight junction injury in all AKI conditions.
UR - http://www.scopus.com/inward/record.url?scp=85083003971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083003971&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2019.12.024
DO - 10.1016/j.kint.2019.12.024
M3 - Comment/debate
C2 - 32331593
AN - SCOPUS:85083003971
SN - 0085-2538
VL - 97
SP - 847
EP - 849
JO - Kidney International
JF - Kidney International
IS - 5
ER -