Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients

Anvita Kale; Sadhana Joshi; Nilesh Naphade; Swati Sapkale; M. S.V.K. Raju; Anilkumar Pillai; Henry Nasrallah; Sahebarao P. Mahadik

doi:10.1016/j.schres.2007.09.036

Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients

Anvita Kale, Sadhana Joshi, Nilesh Naphade, Swati Sapkale, M. S.V.K. Raju, Anilkumar Pillai, Henry Nasrallah, Sahebarao P. Mahadik

Psychiatry and Health Behavior

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.

Original language	English (US)
Pages (from-to)	295-301
Number of pages	7
Journal	Schizophrenia Research
Volume	98
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2007.09.036
State	Published - Jan 2008

Keywords

Arachidonic acid
Cerebrospinal fluid
Docosahexaenoic acid
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2007.09.036

Cite this

@article{4e4ec09d20514e098fbdeaab0d22ec54,

title = "Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients",

abstract = "Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.",

keywords = "Arachidonic acid, Cerebrospinal fluid, Docosahexaenoic acid, Schizophrenia",

author = "Anvita Kale and Sadhana Joshi and Nilesh Naphade and Swati Sapkale and Raju, {M. S.V.K.} and Anilkumar Pillai and Henry Nasrallah and Mahadik, {Sahebarao P.}",

year = "2008",

month = jan,

doi = "10.1016/j.schres.2007.09.036",

language = "English (US)",

volume = "98",

pages = "295--301",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients

AU - Kale, Anvita

AU - Joshi, Sadhana

AU - Naphade, Nilesh

AU - Sapkale, Swati

AU - Raju, M. S.V.K.

AU - Pillai, Anilkumar

AU - Nasrallah, Henry

AU - Mahadik, Sahebarao P.

PY - 2008/1

Y1 - 2008/1

N2 - Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.

AB - Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.

KW - Arachidonic acid

KW - Cerebrospinal fluid

KW - Docosahexaenoic acid

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=37049002256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049002256&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2007.09.036

DO - 10.1016/j.schres.2007.09.036

M3 - Article

C2 - 17997280

AN - SCOPUS:37049002256

SN - 0920-9964

VL - 98

SP - 295

EP - 301

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this