Optimal management of septic shock: Rapid recognition and institution of therapy are crucial

Septic shock is the most common cause of death in intensive care units in the United States, and its incidence is rising. This growth is most likely due to the increased use of invasive devices and immunosuppressive therapies, higher numbers of immunocompromised patients, and increasing antibiotic resistance. In this article, Drs Fitch and Gossage discuss the natural history and diagnosis of septic shock and optimal management, including optimization of organ perfusion, fluid therapy, and use of vasoactive agents.