Oral absorption of radioactive fluoride and iodide in rats

J. R. Patten; G. M. Whitford; G. I. Stringer; D. H. Pashley

doi:10.1016/0003-9969(78)90219-4

Oral absorption of radioactive fluoride and iodide in rats

J. R. Patten, G. M. Whitford, G. I. Stringer, D. H. Pashley

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The absorption of carrier-free ¹⁸F and ¹²⁵I from the mouth was quantitated in anaesthetized rats. Timed blood and urine collections, and several representative tissues, were analyzed for radioactivity and the data used to estimate the fractional absorption of the ¹⁸F and ¹²⁵I doses. After 1, 2 and 3.5 h. the absorption of the ¹²⁵I dose was 7.3, 12.6 and 23.9 per cent, respectively. Radiofluoride absorption was 6.8 per cent after 2.5 h. It is concluded that the oral absorption of fluoride. although readily measurable, occurs more slowly than that of iodide.

Original language	English (US)
Pages (from-to)	215-217
Number of pages	3
Journal	Archives of Oral Biology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/0003-9969(78)90219-4
State	Published - 1978

ASJC Scopus subject areas

Otorhinolaryngology
General Dentistry
Cell Biology

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10.1016/0003-9969(78)90219-4

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@article{93057e35fd0a4959a6a7717541f506f5,

title = "Oral absorption of radioactive fluoride and iodide in rats",

abstract = "The absorption of carrier-free 18F and 125I from the mouth was quantitated in anaesthetized rats. Timed blood and urine collections, and several representative tissues, were analyzed for radioactivity and the data used to estimate the fractional absorption of the 18F and 125I doses. After 1, 2 and 3.5 h. the absorption of the 125I dose was 7.3, 12.6 and 23.9 per cent, respectively. Radiofluoride absorption was 6.8 per cent after 2.5 h. It is concluded that the oral absorption of fluoride. although readily measurable, occurs more slowly than that of iodide.",

author = "Patten, {J. R.} and Whitford, {G. M.} and Stringer, {G. I.} and Pashley, {D. H.}",

note = "Funding Information: Acknowlrdyemrnts-This research was supported in part by NIDR Grant DE-04332 and in part by NIDR Grant DE-03780. Radiofluoride was manufactured under the dirstion of Mr. Robert Kirkland at the Georgia Institute of Technology and was supported by Reactor Sharing Pro gram Contract B-380. We gratefully acknowledge the assistance and support of Dr. J. G. Weatherred",

year = "1978",

doi = "10.1016/0003-9969(78)90219-4",

language = "English (US)",

volume = "23",

pages = "215--217",

journal = "Archives of Oral Biology",

issn = "0003-9969",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Oral absorption of radioactive fluoride and iodide in rats

AU - Patten, J. R.

AU - Whitford, G. M.

AU - Stringer, G. I.

AU - Pashley, D. H.

N1 - Funding Information: Acknowlrdyemrnts-This research was supported in part by NIDR Grant DE-04332 and in part by NIDR Grant DE-03780. Radiofluoride was manufactured under the dirstion of Mr. Robert Kirkland at the Georgia Institute of Technology and was supported by Reactor Sharing Pro gram Contract B-380. We gratefully acknowledge the assistance and support of Dr. J. G. Weatherred

PY - 1978

Y1 - 1978

N2 - The absorption of carrier-free 18F and 125I from the mouth was quantitated in anaesthetized rats. Timed blood and urine collections, and several representative tissues, were analyzed for radioactivity and the data used to estimate the fractional absorption of the 18F and 125I doses. After 1, 2 and 3.5 h. the absorption of the 125I dose was 7.3, 12.6 and 23.9 per cent, respectively. Radiofluoride absorption was 6.8 per cent after 2.5 h. It is concluded that the oral absorption of fluoride. although readily measurable, occurs more slowly than that of iodide.

AB - The absorption of carrier-free 18F and 125I from the mouth was quantitated in anaesthetized rats. Timed blood and urine collections, and several representative tissues, were analyzed for radioactivity and the data used to estimate the fractional absorption of the 18F and 125I doses. After 1, 2 and 3.5 h. the absorption of the 125I dose was 7.3, 12.6 and 23.9 per cent, respectively. Radiofluoride absorption was 6.8 per cent after 2.5 h. It is concluded that the oral absorption of fluoride. although readily measurable, occurs more slowly than that of iodide.

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U2 - 10.1016/0003-9969(78)90219-4

DO - 10.1016/0003-9969(78)90219-4

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AN - SCOPUS:0018148769

SN - 0003-9969

VL - 23

SP - 215

EP - 217

JO - Archives of Oral Biology

JF - Archives of Oral Biology

IS - 3

ER -

Oral absorption of radioactive fluoride and iodide in rats

Abstract

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