Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse

E. H. Weiss; L. Golden; K. Fahrner; A. L. Mellor; J. J. Devlin; H. Bullman; H. Tiddens; H. Bud; R. A. Flavell

doi:10.1038/310650a0

Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse

E. H. Weiss, L. Golden, K. Fahrner, A. L. Mellor, J. J. Devlin, H. Bullman, H. Tiddens, H. Bud, R. A. Flavell

Infectious Disease

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Abstract

The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

Original language	English (US)
Pages (from-to)	650-655
Number of pages	6
Journal	Nature
Volume	310
Issue number	5979
DOIs	https://doi.org/10.1038/310650a0
State	Published - 1984

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title = "Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse",

abstract = "The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.",

author = "Weiss, {E. H.} and L. Golden and K. Fahrner and Mellor, {A. L.} and Devlin, {J. J.} and H. Bullman and H. Tiddens and H. Bud and Flavell, {R. A.}",

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AU - Weiss, E. H.

AU - Golden, L.

AU - Fahrner, K.

AU - Mellor, A. L.

AU - Devlin, J. J.

AU - Bullman, H.

AU - Tiddens, H.

AU - Bud, H.

AU - Flavell, R. A.

PY - 1984

Y1 - 1984

N2 - The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

AB - The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

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Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse

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