TY - JOUR
T1 - Organizing principles of real-time memory encoding
T2 - Neural clique assemblies and universal neural codes
AU - Lin, Longnian
AU - Osan, Remus
AU - Tsien, Joe Z.
N1 - Funding Information:
This work was supported by funds from NIMH and NIA, Burroughs Welcome Fund, ECNU Award, W.M. Keck Foundations, special funds for Major State Basic Research of China (NO2003CB716600), the key project of Chinese ministry of Education (NO104084), and grants from Shanghai Commissions on Science and Technology, and Education.
PY - 2006/1
Y1 - 2006/1
N2 - Recent identification of network-level coding units, termed neural cliques, in the hippocampus has enabled real-time patterns of memory traces to be mathematically described, directly visualized, and dynamically deciphered. These memory coding units are functionally organized in a categorical and hierarchical manner, suggesting that internal representations of external events in the brain is achieved not by recording exact details of those events, but rather by recreating its own selective pictures based on cognitive importance. This neural-clique-based hierarchical-extraction and parallel-binding process enables the brain to acquire not only large storage capacity but also abstraction and generalization capability. In addition, activation patterns of the neural clique assemblies can be converted to strings of binary codes that would permit universal categorizations of internal brain representations across individuals and species.
AB - Recent identification of network-level coding units, termed neural cliques, in the hippocampus has enabled real-time patterns of memory traces to be mathematically described, directly visualized, and dynamically deciphered. These memory coding units are functionally organized in a categorical and hierarchical manner, suggesting that internal representations of external events in the brain is achieved not by recording exact details of those events, but rather by recreating its own selective pictures based on cognitive importance. This neural-clique-based hierarchical-extraction and parallel-binding process enables the brain to acquire not only large storage capacity but also abstraction and generalization capability. In addition, activation patterns of the neural clique assemblies can be converted to strings of binary codes that would permit universal categorizations of internal brain representations across individuals and species.
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U2 - 10.1016/j.tins.2005.11.004
DO - 10.1016/j.tins.2005.11.004
M3 - Review article
C2 - 16325278
AN - SCOPUS:30344481367
SN - 0166-2236
VL - 29
SP - 48
EP - 57
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 1
ER -