TY - JOUR
T1 - Organophosphates, serine esterase inhibition, and modeling of organophosphate toxicity
AU - Chambers, Janice E.
AU - Oppenheimer, Seth F.
PY - 2004/2
Y1 - 2004/2
N2 - The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. The threat of nerve agent exposures at lethal levels regrettably remains a threat to military as well as civilian populations, and the authors of this article have used their previous experimental data along with new in vitro data to devise and calibrate a mathematical model that could have practical utility in the prophylaxis of military personnel against chemical warfare agents.
AB - The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. The threat of nerve agent exposures at lethal levels regrettably remains a threat to military as well as civilian populations, and the authors of this article have used their previous experimental data along with new in vitro data to devise and calibrate a mathematical model that could have practical utility in the prophylaxis of military personnel against chemical warfare agents.
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U2 - 10.1093/toxsci/kfh060
DO - 10.1093/toxsci/kfh060
M3 - Article
C2 - 14992203
AN - SCOPUS:1342267739
SN - 1096-6080
VL - 77
SP - 185
EP - 187
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 2
ER -