TY - JOUR
T1 - Osteoblastoma characterized by a three-way translocation
T2 - report of a case and review of the literature
AU - Giannico, Giovanna
AU - Holt, Ginger E.
AU - Homlar, Kelly C.
AU - Johnson, Joyce
AU - Pinnt, Jeffrey
AU - Bridge, Julia A.
N1 - Funding Information:
The authors would like to thank Ms. Patti Cattano for her technical assistance and Dr. Cheryl M. Coffin for her publication support. These studies were supported in part by a University of Nebraska Medical Center (UNMC) Eppley Cancer Center Pediatric Research Award.
PY - 2009/12
Y1 - 2009/12
N2 - Osteoblastoma, an uncommon primary bone tumor, produces both osteoid and primitive woven bone in a background of fibrovascular connective tissue. Although most osteoblastomas are considered benign, a controversial aggressive variant has been described, which may cause diagnostic confusion with malignant tumors such as osteosarcoma. To date, no specific diagnostic cytogenetic or molecular marker has been identified for osteoblastoma to aid in its distinction. Conventional cytogenetic analysis of an osteoblastoma arising in the femur of a 23-year-old woman revealed a novel three-way translocation involving chromosomes 1, 2 and 14 [t(1;2;14) (q42;q13;q24)]. Rearrangement of 1q42 has been identified in a previously reported case.
AB - Osteoblastoma, an uncommon primary bone tumor, produces both osteoid and primitive woven bone in a background of fibrovascular connective tissue. Although most osteoblastomas are considered benign, a controversial aggressive variant has been described, which may cause diagnostic confusion with malignant tumors such as osteosarcoma. To date, no specific diagnostic cytogenetic or molecular marker has been identified for osteoblastoma to aid in its distinction. Conventional cytogenetic analysis of an osteoblastoma arising in the femur of a 23-year-old woman revealed a novel three-way translocation involving chromosomes 1, 2 and 14 [t(1;2;14) (q42;q13;q24)]. Rearrangement of 1q42 has been identified in a previously reported case.
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U2 - 10.1016/j.cancergencyto.2009.06.024
DO - 10.1016/j.cancergencyto.2009.06.024
M3 - Article
C2 - 19963118
AN - SCOPUS:70949083968
SN - 0165-4608
VL - 195
SP - 168
EP - 171
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
