TY - JOUR
T1 - Osteoinduction in young and old rats using demineralized bone powder allografts
AU - Hosny, Mahmoud
AU - Sharawy, Mohamed
N1 - Funding Information:
From the Department of Oral Biology and Anatomy, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912. (Dr. Hosny is currently a resident in the Oral and Maxillofacial Surgery Department at Tnfts University.) * This study was done while Dr. Hosny was a Peace Fellow in the Department of Oral Biology/Anatomy. Medical College of Georgia. Supported in part by Amideast Company Grant No. IO-12-02-1122-63. Address correspondence and reprint requests to Dr. Sharawy.
PY - 1985/12
Y1 - 1985/12
N2 - The process of inducing differentiated and undifferentiated cells to become osteogenic using demineralized bone powder (DBP) is a well-known phenomenon in developmental biology. The aim of this study was to examine whether age has an effect on the process of bone induction. DBP was implanted in the subcutaneous thoracic tissue of young rats (28-56 days) and old rats (14 months or older), and the animals were examined seven, 12, 20, and 60 days after implantation. The amount of newly induced bone in the implant was quantitatively measured using histomorphometry and 45Ca uptake. Undecalcified and decalcified specimens were processed for histologic examination using several stains that demonstrate osteoid. Both the young rats and the old rats formed bone in response to the DBP implants. In old animals the induced bone appeared to be less in quantity, it formed at a slower rate, and it exhibited less bone marrow cellularity than did the bone in young animals.
AB - The process of inducing differentiated and undifferentiated cells to become osteogenic using demineralized bone powder (DBP) is a well-known phenomenon in developmental biology. The aim of this study was to examine whether age has an effect on the process of bone induction. DBP was implanted in the subcutaneous thoracic tissue of young rats (28-56 days) and old rats (14 months or older), and the animals were examined seven, 12, 20, and 60 days after implantation. The amount of newly induced bone in the implant was quantitatively measured using histomorphometry and 45Ca uptake. Undecalcified and decalcified specimens were processed for histologic examination using several stains that demonstrate osteoid. Both the young rats and the old rats formed bone in response to the DBP implants. In old animals the induced bone appeared to be less in quantity, it formed at a slower rate, and it exhibited less bone marrow cellularity than did the bone in young animals.
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U2 - 10.1016/0278-2391(85)90004-7
DO - 10.1016/0278-2391(85)90004-7
M3 - Article
C2 - 3906057
AN - SCOPUS:0022407160
SN - 0278-2391
VL - 43
SP - 925
EP - 931
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 12
ER -