Osteoporosis prevention in an extraordinary hibernating bear

Seth W. Donahue; Samantha J. Wojda; Meghan E. McGee-Lawrence; Janene Auger; Hal L. Black

doi:10.1016/j.bone.2021.115845

Osteoporosis prevention in an extraordinary hibernating bear

Seth W. Donahue, Samantha J. Wojda, Meghan E. McGee-Lawrence, Janene Auger, Hal L. Black

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed.

Original language	English (US)
Article number	115845
Journal	Bone
Volume	145
DOIs	https://doi.org/10.1016/j.bone.2021.115845
State	Published - Apr 2021

Keywords

Bone adaptation
Bone remodeling
Disuse osteoporosis
Hibernation

ASJC Scopus subject areas

Physiology
Endocrinology, Diabetes and Metabolism
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bone.2021.115845

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title = "Osteoporosis prevention in an extraordinary hibernating bear",

abstract = "Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed.",

keywords = "Bone adaptation, Bone remodeling, Disuse osteoporosis, Hibernation",

author = "Donahue, {Seth W.} and Wojda, {Samantha J.} and McGee-Lawrence, {Meghan E.} and Janene Auger and Black, {Hal L.}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

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doi = "10.1016/j.bone.2021.115845",

language = "English (US)",

volume = "145",

journal = "Bone",

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T1 - Osteoporosis prevention in an extraordinary hibernating bear

AU - Donahue, Seth W.

AU - Wojda, Samantha J.

AU - McGee-Lawrence, Meghan E.

AU - Auger, Janene

AU - Black, Hal L.

PY - 2021/4

Y1 - 2021/4

N2 - Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed.

AB - Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed.

KW - Bone adaptation

KW - Bone remodeling

KW - Disuse osteoporosis

KW - Hibernation

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VL - 145

JO - Bone

JF - Bone

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ER -

Osteoporosis prevention in an extraordinary hibernating bear

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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