p16 and ARF: activation of teenage proteins in old age.

Satyanarayana Ande; K. Lenhard Rudolph

p16 and ARF: activation of teenage proteins in old age.

Satyanarayana Ande
, K. Lenhard Rudolph

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

Original language	English (US)
Pages (from-to)	1237-1240
Number of pages	4
Journal	The Journal of clinical investigation
Volume	114
Issue number	9
State	Published - Nov 1 2004
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "p16 and ARF: activation of teenage proteins in old age.",

abstract = "Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.",

author = "Satyanarayana Ande and Rudolph, \{K. Lenhard\}",

year = "2004",

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language = "English (US)",

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pages = "1237--1240",

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TY - JOUR

T1 - p16 and ARF

T2 - activation of teenage proteins in old age.

AU - Ande, Satyanarayana

AU - Rudolph, K. Lenhard

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

AB - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

UR - https://www.scopus.com/pages/publications/15244360933

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M3 - Comment/debate

C2 - 15520854

SN - 0021-9738

VL - 114

SP - 1237

EP - 1240

JO - The Journal of clinical investigation

JF - The Journal of clinical investigation

IS - 9

ER -

p16 and ARF: activation of teenage proteins in old age.

Abstract

ASJC Scopus subject areas

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