TY - JOUR
T1 - p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury
AU - Kar, Parmita
AU - Sivasailam, Ashok
AU - Lavarti, Rupa
AU - Cai, Lun
AU - Thangaraju, Muthusamy
AU - Nguyen, Emma
AU - Mundluru, Bhavishya
AU - Raju, Raghavan Pillai
N1 - Publisher Copyright:
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.
PY - 2024/12
Y1 - 2024/12
N2 - The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.
AB - The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.
UR - http://www.scopus.com/inward/record.url?scp=85206365036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85206365036&partnerID=8YFLogxK
U2 - 10.1038/s41514-024-00175-z
DO - 10.1038/s41514-024-00175-z
M3 - Article
AN - SCOPUS:85206365036
SN - 2056-3973
VL - 10
JO - npj Aging
JF - npj Aging
IS - 1
M1 - 45
ER -