Pain Control by Image-Guided Radiosurgery for Solitary Spinal Metastasis

Samuel Ryu, Ryan Jin, Jian Yue Jin, Qing Chen, Jack Rock, Joseph Anderson, Benjamin Movsas

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Precision and accuracy of image-guided spinal radiosurgery has been previously demonstrated. This study was carried out to determine the clinical efficacy of spine radiosurgery for the treatment of solitary spinal metastases with or without cord compression. A total of 49 patients with 61 separate spinal metastases were treated with radiosurgery. All patients had pathologically proven primary cancers and had either synchronous or metachronous metastasis to the spine. The majority of the patients presented with back pain. All patients received single-dose radiosurgery to the involved spine only. The radiosurgery dose ranged from 10 to 16 Gy. The primary endpoint was pain control, but outcomes in neurological status and radiological tumor control also were assessed. The median time to pain relief was 14 days and the earliest time of pain relief was within 24 hours. Complete pain relief was achieved in 46%, partial relief in 18.9%, and stable symptoms in 16.2%. Relapse of pain at the treated spinal segment was 6.9%. Median duration of pain relief at the treated spine was 13.3 months. Overall pain control rate for one year was 84%. This experience demonstrates that spinal radiosurgery can achieve rapid and durable pain relief. Single-dose radiosurgery has a potential to be a viable treatment option for single spinal metastasis.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
JournalJournal of Pain and Symptom Management
Issue number3
StatePublished - Mar 2008
Externally publishedYes


  • Pain control
  • spine metastasis
  • spine radiosurgery
  • stereotactic radiosurgery

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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