Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Carlos P. Griswold, Nisaraporn Suthiwangcharoen, Steven M. Pochini, Chad E. Stephens

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

    Original languageEnglish (US)
    Pages (from-to)1672-1681
    Number of pages10
    JournalSynthetic Communications
    Issue number11
    StatePublished - 2011


    • 2-Aminopyrrole
    • DPEphos
    • N-arylation
    • Palladium-catalyzed
    • Pyrrolo[2,3-d] pyrido[1,2-a]pyrimidine
    • Xantphos

    ASJC Scopus subject areas

    • Organic Chemistry


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