Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Carlos P. Griswold; Nisaraporn Suthiwangcharoen; Steven M. Pochini; Chad E. Stephens

doi:10.1080/00397911.2010.492073

Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Carlos P. Griswold, Nisaraporn Suthiwangcharoen, Steven M. Pochini, Chad E. Stephens

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

Original language	English (US)
Pages (from-to)	1672-1681
Number of pages	10
Journal	Synthetic Communications
Volume	41
Issue number	11
DOIs	https://doi.org/10.1080/00397911.2010.492073
State	Published - 2011

Keywords

2-Aminopyrrole
DPEphos
N-arylation
Palladium-catalyzed
Pyrrolo[2,3-d] pyrido[1,2-a]pyrimidine
Xantphos

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397911.2010.492073

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title = "Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles",

abstract = "A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.",

keywords = "2-Aminopyrrole, DPEphos, N-arylation, Palladium-catalyzed, Pyrrolo[2,3-d] pyrido[1,2-a]pyrimidine, Xantphos",

author = "Griswold, {Carlos P.} and Nisaraporn Suthiwangcharoen and Pochini, {Steven M.} and Stephens, {Chad E.}",

note = "Funding Information: We thank our department and the Pamplin College of Arts and Sciences for funding of this research.",

year = "2011",

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language = "English (US)",

volume = "41",

pages = "1672--1681",

journal = "Synthetic Communications",

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T1 - Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

AU - Griswold, Carlos P.

AU - Suthiwangcharoen, Nisaraporn

AU - Pochini, Steven M.

AU - Stephens, Chad E.

N1 - Funding Information: We thank our department and the Pamplin College of Arts and Sciences for funding of this research.

PY - 2011

Y1 - 2011

N2 - A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

AB - A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

KW - 2-Aminopyrrole

KW - DPEphos

KW - N-arylation

KW - Palladium-catalyzed

KW - Pyrrolo[2,3-d] pyrido[1,2-a]pyrimidine

KW - Xantphos

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DO - 10.1080/00397911.2010.492073

M3 - Article

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SN - 0039-7911

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SP - 1672

EP - 1681

JO - Synthetic Communications

JF - Synthetic Communications

IS - 11

ER -

Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Abstract

Keywords

ASJC Scopus subject areas

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