Abstract
The evaluation of palmitate oxidation in muscle tissue may be a useful screening test for detecting defects in fatty acid metabolism in human neuromuscular disease. If the test is to be useful, it is necessary to obtain data on a wide variety of muscle illnesses for comparative purposes. We report our experience with palmitate oxidation, muscle carnitine, and carnitine palmityl transferase (CPT) activity in 148 muscle biopsies from a variety of illnesses. The efficacy of using total protein, citrate synthase, and (1‐14C) pyruvate oxidation as internal references was investigated. Palmitate oxidation was significantly less than normal (P ≤ 0.01) in Duchenne muscular dystrophy, congenital nonprogressive myopathy, congenital muscular dystrophy, malignant hyperpyrexia, and denervation, depending on the internal reference used. Muscle carnitine levels followed a similar pattern, however, CPT activity did not. The possibility of these findings being secondary to inactivity is discussed.
Original language | English (US) |
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Pages (from-to) | 226-231 |
Number of pages | 6 |
Journal | Muscle & Nerve |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)