Abstract
With the number of designer drugs on the streets rampantly on the rise, it's becoming more and more important to be able to rapidly characterize them in a biologically relevant way. Using a parallel artificial membrane permeability assay (PAMPA) to assess the blood brain barrier permeability has shown to be a high throughput way to compare new drugs with currently controlled substances via their effective permeability values. This combined with direct infusion electrospray ionization-mass spectrometry creates a rapid technique for characterization of new designer drugs. PAMPA has successfully determined the effective permeabilities of cocaine, methamphetamine, heroin, MDMA, and several tryptamine derivatives.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 351-355 |
| Number of pages | 5 |
| Journal | Science and Justice - Journal of the Forensic Science Society |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2014 |
| Externally published | Yes |
Keywords
- Blood-brain barrier
- Drug analogues
- ESI-MS
- Illicit drugs
- Parallel artificial membrane permeability assay
ASJC Scopus subject areas
- Pathology and Forensic Medicine
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