TY - JOUR
T1 - Pathophysiological Considerations in Periorbital Necrotizing Fasciitis
T2 - A Case Report
AU - Hadizamani, Yalda
AU - Anastasi, Stefano
AU - Schori, Anouk
AU - Lucas, Rudolf
AU - Garweg, Justus G.
AU - Hamacher, Jürg
N1 - Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Background: Periorbital necrotizing fasciitis (PNF) is a rare complication of bacterial infection, associated with irreversible inflammatory destruction of soft tissues like subcutaneous tissue and superficial fascia. PNF can cause visual loss, septic shock and death within hours to days. Since the infection progresses rapidly from a local disease to septic shock, prompt identification and decisive interventions are mandatory. Aim: Considering pathophysiology, differential diagnosis, and treatment options, we report a case of PNF and its outcome. Methods: A 69 years old male with febrile periorbital swelling had been diagnosed with bilateral PNF, caused by dual infection with Streptococcus pyogenes (S. pyogenes) and Staphylococcus aureus (S. aureus) based on conjunctival swabs. Results: The superantigens produced by S. pyogenes have been identified as key to the rapid dissemination of infection and severity of systemic manifestations. Conclusion: A combination of intravenous antibiotics and regular surgical debridements resulted in a beneficial outcome in our patient.
AB - Background: Periorbital necrotizing fasciitis (PNF) is a rare complication of bacterial infection, associated with irreversible inflammatory destruction of soft tissues like subcutaneous tissue and superficial fascia. PNF can cause visual loss, septic shock and death within hours to days. Since the infection progresses rapidly from a local disease to septic shock, prompt identification and decisive interventions are mandatory. Aim: Considering pathophysiology, differential diagnosis, and treatment options, we report a case of PNF and its outcome. Methods: A 69 years old male with febrile periorbital swelling had been diagnosed with bilateral PNF, caused by dual infection with Streptococcus pyogenes (S. pyogenes) and Staphylococcus aureus (S. aureus) based on conjunctival swabs. Results: The superantigens produced by S. pyogenes have been identified as key to the rapid dissemination of infection and severity of systemic manifestations. Conclusion: A combination of intravenous antibiotics and regular surgical debridements resulted in a beneficial outcome in our patient.
KW - Periorbital necrotizing fasciitis
KW - Staphylococcus aureus
KW - Streptococcus pyogenes
KW - antibiotic
KW - superantigens
KW - surgical debridement
KW - toxic shock syndrome
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U2 - 10.1080/09273948.2022.2032190
DO - 10.1080/09273948.2022.2032190
M3 - Letter
C2 - 35404751
AN - SCOPUS:85129128920
SN - 0927-3948
VL - 31
SP - 468
EP - 473
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 2
ER -