Pathophysiology of varicocele in nonhuman primates: Long-term seminal and testicular changes

R. M. Harrison, R. W. Lewis, J. A. Roberts

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e., for more than 2 years. Testicular blood flow was depressed acutely but returned to normal after 2 years. Electron microscopy showed changes in the basal lamina and spermatogonia that persisted throughout the study. Left adrenalectomy, at the time of varicocele induction, did not alter the development of varicocele-related changes. The sequence of changes suggests that the effects of this experimental varicocele may be reversed in the monkey model through changes in collateral and ancillary revascularization.

Original languageEnglish (US)
Pages (from-to)500-510
Number of pages11
JournalFertility and sterility
Issue number3
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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