TY - JOUR
T1 - Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome
AU - Cherry, Mohamad
AU - Cardenas-Turanzas, Marylou
AU - Pham, Hannah
AU - Kantarjian, Hagop
AU - Cortes, Jorge
AU - Pierce, Sherry
AU - Zhou, Lingsha
AU - Verstovsek, Srdan
N1 - Funding Information:
This research is supported in part by the MD Anderson Cancer Center Support Grant CA016672 . We highly appreciate the help of Kate Newberry, PhD for scientific editing and Dr. Ali Alameri for his help with data collection.
PY - 2013/11
Y1 - 2013/11
N2 - The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.
AB - The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.
KW - Essential thrombocythemia
KW - Myeloproliferative disorders
KW - Polycythemia vera
KW - Prior malignancy
KW - Transformation to acute leukemia
KW - Transformation to myelofibrosis
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U2 - 10.1016/j.leukres.2013.08.002
DO - 10.1016/j.leukres.2013.08.002
M3 - Article
C2 - 23993426
AN - SCOPUS:84886772830
SN - 0145-2126
VL - 37
SP - 1472
EP - 1476
JO - Leukemia Research
JF - Leukemia Research
IS - 11
ER -