Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome

Mohamad Cherry; Marylou Cardenas-Turanzas; Hannah Pham; Hagop Kantarjian; Jorge Cortes; Sherry Pierce; Lingsha Zhou; Srdan Verstovsek

doi:10.1016/j.leukres.2013.08.002

Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome

Mohamad Cherry
, Marylou Cardenas-Turanzas
, Hannah Pham
, Hagop Kantarjian
, Jorge Cortes
, Sherry Pierce
, Lingsha Zhou
, Srdan Verstovsek

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.

Original language	English (US)
Pages (from-to)	1472-1476
Number of pages	5
Journal	Leukemia Research
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2013.08.002
State	Published - Nov 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Essential thrombocythemia
Myeloproliferative disorders
Polycythemia vera
Prior malignancy
Transformation to acute leukemia
Transformation to myelofibrosis

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/j.leukres.2013.08.002

Cite this

@article{c56efd9c8fd54336b17cbd319cc694c4,

title = "Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome",

abstract = "The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10\%; PV, 11\%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.",

keywords = "Essential thrombocythemia, Myeloproliferative disorders, Polycythemia vera, Prior malignancy, Transformation to acute leukemia, Transformation to myelofibrosis",

author = "Mohamad Cherry and Marylou Cardenas-Turanzas and Hannah Pham and Hagop Kantarjian and Jorge Cortes and Sherry Pierce and Lingsha Zhou and Srdan Verstovsek",

note = "Funding Information: This research is supported in part by the MD Anderson Cancer Center Support Grant CA016672 . We highly appreciate the help of Kate Newberry, PhD for scientific editing and Dr. Ali Alameri for his help with data collection. ",

year = "2013",

month = nov,

doi = "10.1016/j.leukres.2013.08.002",

language = "English (US)",

volume = "37",

pages = "1472--1476",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "11",

}

TY - JOUR

T1 - Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome

AU - Cherry, Mohamad

AU - Cardenas-Turanzas, Marylou

AU - Pham, Hannah

AU - Kantarjian, Hagop

AU - Cortes, Jorge

AU - Pierce, Sherry

AU - Zhou, Lingsha

AU - Verstovsek, Srdan

N1 - Funding Information: This research is supported in part by the MD Anderson Cancer Center Support Grant CA016672 . We highly appreciate the help of Kate Newberry, PhD for scientific editing and Dr. Ali Alameri for his help with data collection.

PY - 2013/11

Y1 - 2013/11

N2 - The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.

AB - The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n= 263; PV, n= 174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.

KW - Essential thrombocythemia

KW - Myeloproliferative disorders

KW - Polycythemia vera

KW - Prior malignancy

KW - Transformation to acute leukemia

KW - Transformation to myelofibrosis

UR - https://www.scopus.com/pages/publications/84886772830

UR - https://www.scopus.com/pages/publications/84886772830#tab=citedBy

U2 - 10.1016/j.leukres.2013.08.002

DO - 10.1016/j.leukres.2013.08.002

M3 - Article

C2 - 23993426

AN - SCOPUS:84886772830

SN - 0145-2126

VL - 37

SP - 1472

EP - 1476

JO - Leukemia Research

JF - Leukemia Research

IS - 11

ER -

Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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