TY - JOUR
T1 - Patterns of body fat deposition in youth and their relation to left ventricular markers of adverse cardiovascular prognosis
AU - Mensah, George A.
AU - Treiber, Frank A.
AU - Kapuku, Gaston K.
AU - Davis, Harry
AU - Barnes, Vernon A.
AU - Strong, William B.
N1 - Funding Information:
This study was supported in part by Grants HL-41781 and HL-35073 from the National Institutes of Health, Bethesda, Maryland. Manuscript received December 15, 1998; revised manuscript received and accepted April 27, 1999.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - The patterns of body fat deposition in healthy youth and their relation to future development of cardiovascular disease remain incompletely understood. To further evaluate these patterns, we measured indirect indexes of central and general fat deposition in healthy adolescents (mean age 15.4 ± 2.3 years) with family histories of hypertension. We examined the relation between these indexes and echocardiographic markers of adverse prognosis as well as the effect of gender and ethnicity. All 225 subjects (64% black and 48% female) had ≥1 biologic parent and 1 grandparent with hypertension. Skinfold thicknesses, waist-to-hip girth ratio, Quetelet index, Ponderal index, conicity, and Z score weight - Z score height were measured. Left ventricular (LV) mass, indexed LV mass, relative wall thickness (RWT), and midwall fractional shortening (MFS) were determined using echocardiography. In both black and white subjects, the adiposity indexes were significantly correlated with posterior wall thickness, total LV mass, and indexed LV mass (p <0.05 for all). Additionally, in black subjects, central adiposity was inversely related to MFS and directly related to RWT and septal thickness. General adiposity independently predicted indexed and nonindexed LV mass, whereas central adiposity predicted MFS and RWT. Compared with subjects with normal LV geometry, those with abnormal geometry were heavier and fatter based on every index of obesity (p <0.03 for all). Thus, indexes of fat deposition are significantly correlated with LV markers of adverse prognosis in healthy youth. Copyright (C) 1999 Excerpta Medica Inc.
AB - The patterns of body fat deposition in healthy youth and their relation to future development of cardiovascular disease remain incompletely understood. To further evaluate these patterns, we measured indirect indexes of central and general fat deposition in healthy adolescents (mean age 15.4 ± 2.3 years) with family histories of hypertension. We examined the relation between these indexes and echocardiographic markers of adverse prognosis as well as the effect of gender and ethnicity. All 225 subjects (64% black and 48% female) had ≥1 biologic parent and 1 grandparent with hypertension. Skinfold thicknesses, waist-to-hip girth ratio, Quetelet index, Ponderal index, conicity, and Z score weight - Z score height were measured. Left ventricular (LV) mass, indexed LV mass, relative wall thickness (RWT), and midwall fractional shortening (MFS) were determined using echocardiography. In both black and white subjects, the adiposity indexes were significantly correlated with posterior wall thickness, total LV mass, and indexed LV mass (p <0.05 for all). Additionally, in black subjects, central adiposity was inversely related to MFS and directly related to RWT and septal thickness. General adiposity independently predicted indexed and nonindexed LV mass, whereas central adiposity predicted MFS and RWT. Compared with subjects with normal LV geometry, those with abnormal geometry were heavier and fatter based on every index of obesity (p <0.03 for all). Thus, indexes of fat deposition are significantly correlated with LV markers of adverse prognosis in healthy youth. Copyright (C) 1999 Excerpta Medica Inc.
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U2 - 10.1016/S0002-9149(99)00383-5
DO - 10.1016/S0002-9149(99)00383-5
M3 - Article
C2 - 10482160
AN - SCOPUS:0032840328
SN - 0002-9149
VL - 84
SP - 583
EP - 588
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 5
ER -