Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons

H. A. Savchenko; A. A. Vasylevs'kyǐ; K. A. Pluzhnykov; I. V. Korol'kova; M. V. Mamenko; T. M. Volkova; O. P. Maksymiuk; I. A. Boǐchuk; I. V. Hrishyn; O. O. Kryshtal'

Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons

H. A. Savchenko, A. A. Vasylevs'kyǐ, K. A. Pluzhnykov, I. V. Korol'kova, M. V. Mamenko, T. M. Volkova, O. P. Maksymiuk, I. A. Boǐchuk, I. V. Hrishyn, O. O. Kryshtal'

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

Original language	English (US)
Pages (from-to)	11-16
Number of pages	6
Journal	Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994)
Volume	55
Issue number	2
State	Published - Aug 12 2009
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons",

abstract = "Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.",

author = "Savchenko, {H. A.} and Vasylevs'kyǐ, {A. A.} and Pluzhnykov, {K. A.} and Korol'kova, {I. V.} and Mamenko, {M. V.} and Volkova, {T. M.} and Maksymiuk, {O. P.} and Boǐchuk, {I. A.} and Hrishyn, {I. V.} and Kryshtal', {O. O.}",

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T1 - Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons

AU - Savchenko, H. A.

AU - Vasylevs'kyǐ, A. A.

AU - Pluzhnykov, K. A.

AU - Korol'kova, I. V.

AU - Mamenko, M. V.

AU - Volkova, T. M.

AU - Maksymiuk, O. P.

AU - Boǐchuk, I. A.

AU - Hrishyn, I. V.

AU - Kryshtal', O. O.

PY - 2009/8/12

Y1 - 2009/8/12

N2 - Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

AB - Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

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Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons

Abstract

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