Peptides of CD200 Modulate LPS-Induced TNF-α Induction and Mortality In Vivo

Reg Gorczynski, Ivo Boudakov, Ismat Khatri

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R, expressed on cells of myeloid and lymphoid origin, delivers immunoregulatory signals that modulate inflammation in a number of diseases, including transplant rejection and arthritis. A number of isoforms of CD200R have been described in mice with distinct function. We have synthesized small (9-13 mer) peptides defining distinct regions of CD200, and asked whether different peptides would function as agonists and/or antagonists of different CD200R isoforms. The assays used to characterize these functions include a model of inflammation and tumor necrosis factor-alpha production induced following lipopolysaccharide administration in vivo, and mixed leukocyte cultures in vitro. Discrete agonist and antagonist peptides were defined for different CD200Rs, which suggests this approach may have some clinical utility.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalJournal of Surgical Research
Volume145
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • immunoglobulin superfamily
  • immunosuppression
  • inflammation
  • tolerance

ASJC Scopus subject areas

  • Surgery

Fingerprint

Dive into the research topics of 'Peptides of CD200 Modulate LPS-Induced TNF-α Induction and Mortality In Vivo'. Together they form a unique fingerprint.

Cite this