Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sandhyamayee Sahu; Iryna O. Lebedyeva; Siva S. Panda; Alan R. Katritzky

doi:10.1055/s-0033-1338473

Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sandhyamayee Sahu, Iryna O. Lebedyeva, Siva S. Panda, Alan R. Katritzky

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.

Original language	English (US)
Article number	SS-2012-M0978-OP
Pages (from-to)	1256-1260
Number of pages	5
Journal	Synthesis (Germany)
Volume	45
Issue number	9
DOIs	https://doi.org/10.1055/s-0033-1338473
State	Published - 2013
Externally published	Yes

Keywords

acylations
cyclizations
drugs
heterocycles
nitriles
peptides

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0033-1338473

Cite this

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title = "Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups",

abstract = "Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.",

keywords = "acylations, cyclizations, drugs, heterocycles, nitriles, peptides",

author = "Sandhyamayee Sahu and Lebedyeva, {Iryna O.} and Panda, {Siva S.} and Katritzky, {Alan R.}",

year = "2013",

doi = "10.1055/s-0033-1338473",

language = "English (US)",

volume = "45",

pages = "1256--1260",

journal = "Synthesis (Germany)",

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publisher = "Georg Thieme Verlag",

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T1 - Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

AU - Sahu, Sandhyamayee

AU - Lebedyeva, Iryna O.

AU - Panda, Siva S.

AU - Katritzky, Alan R.

PY - 2013

Y1 - 2013

N2 - Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.

AB - Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.

KW - acylations

KW - cyclizations

KW - drugs

KW - heterocycles

KW - nitriles

KW - peptides

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U2 - 10.1055/s-0033-1338473

DO - 10.1055/s-0033-1338473

M3 - Article

AN - SCOPUS:84876695077

SN - 0039-7881

VL - 45

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JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 9

M1 - SS-2012-M0978-OP

ER -

Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Abstract

Keywords

ASJC Scopus subject areas

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