TY - JOUR
T1 - Periodontal healing following reconstructive surgery
T2 - Effect of guided tissue regeneration using a bioresorbable barrier device when combined with autogenous bone grafting. A randomized controlled clinical trial
AU - Nygaard-Østby, Per
AU - Bakke, Vibeke
AU - Nesdal, Oddny
AU - Nilssen, Helene Klerck
AU - Susin, Cristiano
AU - Wikesjö, Ulf M E
PY - 2008/1
Y1 - 2008/1
N2 - Objective: The objective of this randomized-controlled clinical trial was to evaluate the adjunctive effect of guided tissue regeneration (GTR) using a bioresorbable polylactic acid (PLA) barrier device when combined with autogenous bone grafting in the treatment of deep intra-bony periodontal defects. Material and Methods: Forty systemically healthy patients (20 females; mean age 53 years; non-smokers) participated in the study. Using a parallel-group study design, one intra-bony defect in each of 20 subjects received GTR using the bioresorbable PLA barrier device (Atrisorb®), combined with autogenous bone grafting. One intra-bony defect in each of the remaining 20 subjects received bone grafting solo (control). Treatments were evaluated at 9 months post-surgery. Results: One patient (GTR) was withdrawn from the study due to circumstances unrelated to the study. Eighty-nine per cent of the PLA barriers became exposed within 3 weeks following surgery. Pre-surgery probing depths for GTR and control intra-bony defects averaged (±SE) 7.1±0.3 mm. Significant probing depth reduction (2.7±0.3 versus 2.4±0.4 mm), attachment-level gain (1.7±0.3 versus 1.7±0.5 mm), and bone fill (1.2±0.4 versus 1.2±0.5 mm) were observed for the GTR and control sites, respectively (p≤0.02). However, there were no statistically significant differences between treatment protocols. Conclusions: The results suggest that GTR using the bioresorbable PLA barrier device does not provide additional value to reconstructive surgery including autogenous bone grafting in intra-bony periodontal defects.
AB - Objective: The objective of this randomized-controlled clinical trial was to evaluate the adjunctive effect of guided tissue regeneration (GTR) using a bioresorbable polylactic acid (PLA) barrier device when combined with autogenous bone grafting in the treatment of deep intra-bony periodontal defects. Material and Methods: Forty systemically healthy patients (20 females; mean age 53 years; non-smokers) participated in the study. Using a parallel-group study design, one intra-bony defect in each of 20 subjects received GTR using the bioresorbable PLA barrier device (Atrisorb®), combined with autogenous bone grafting. One intra-bony defect in each of the remaining 20 subjects received bone grafting solo (control). Treatments were evaluated at 9 months post-surgery. Results: One patient (GTR) was withdrawn from the study due to circumstances unrelated to the study. Eighty-nine per cent of the PLA barriers became exposed within 3 weeks following surgery. Pre-surgery probing depths for GTR and control intra-bony defects averaged (±SE) 7.1±0.3 mm. Significant probing depth reduction (2.7±0.3 versus 2.4±0.4 mm), attachment-level gain (1.7±0.3 versus 1.7±0.5 mm), and bone fill (1.2±0.4 versus 1.2±0.5 mm) were observed for the GTR and control sites, respectively (p≤0.02). However, there were no statistically significant differences between treatment protocols. Conclusions: The results suggest that GTR using the bioresorbable PLA barrier device does not provide additional value to reconstructive surgery including autogenous bone grafting in intra-bony periodontal defects.
KW - Barrier membrane
KW - Bone graft
KW - Guided tissue regeneration
KW - Periodontal regeneration
KW - Polylactic acid
KW - Wound healing
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U2 - 10.1111/j.1600-051X.2007.01160.x
DO - 10.1111/j.1600-051X.2007.01160.x
M3 - Article
C2 - 18173400
AN - SCOPUS:37349003694
SN - 0303-6979
VL - 35
SP - 37
EP - 43
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 1
ER -