Periodontal Regeneration: Focus on Growth and Differentiation Factors

Jaebum Lee, Andreas Stavropoulos, Cristiano Susin, Ulf M E Wikesjö

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.

Original languageEnglish (US)
Pages (from-to)93-111
Number of pages19
JournalDental clinics of North America
Issue number1
StatePublished - Jan 1 2010


  • Differentiation factors
  • Growth factors
  • Periodontal regeneration
  • Preclinical study

ASJC Scopus subject areas

  • Dentistry(all)


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